Construction of the dual-functional RNA ligand against HCV NS3 protease and helicase
نویسندگان
چکیده
منابع مشابه
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase.
Hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses multiple enzyme activities. The N-terminal one-third of NS3 primarily functions as a serine protease, while the remaining two-thirds of NS3 serve as a helicase and nucleoside triphosphatase. Whether the multiple enzyme activities of NS3 are functionally interdependent and/or modulated by other viral NS proteins remains unclear. We ...
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ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2001
ISSN: 0261-3166,1746-8272
DOI: 10.1093/nass/1.1.147